Leslie Tyrone graduated Princeton University with an A.B. in Architecture, and Columbia University with a Masters in Architecture.

She traveled to Berlin on a Getty Travel Grant to study Mies van der Rohe's European work in conjunction with a show at the MoMA by Terry Riley and Barry Bergdoll entitled "Mies in Berlin". She was Columbia University's Ware Slide Library Curator for two years while in school.

After finishing Columbia she worked for Skidmore Owings & Merrill in the transportation group, then returned home to Atlanta to work for Perkins + Will in the education group. She then spent a year working on public art proposals and art gallery projects for Amy Landesberg Architects, including a successful competition entry for Hartsfield Jackson International Airport public art and Mason Murer Fine Art Gallery.

In 2005 Leslie founded Leslie Tyrone, Architect, a firm focusing on residential and small commercial architecture and interior design. In April 2007 Leslie participated in the ATL: MODERN events. She taught a graduate level architecture design studio at Georgia Tech in 2007 and 2008, as well as a studio course entitled "The Theory of Interior Design" at the Ernest G. Welch School of Art + Design at Georgia State.

Current projects include: Renovation of the Castle in Midtown Atlanta, the house-lifting and complete renovation of a Peachtree Battle area home that was severely damaged in the 2009 Atlanta floods, and an off-the-grid vacation home outside of Breckenridge, Colorado.